Lately we have got for execution a quite huge anonymous PL/SQL block (~10M). When it went for execution it failed with ORA-4030.
There are limits to the size of a PL/SQL block. They may be rised at the OS level or in the database (look at "ORA-4030 (PLSQL Opt Pool,pdziM01_Create: New Set), ORA-4030 (PLS CGA hp,pdzgM64_New_Link)" (Doc ID 1551115.1) on the Metalink).
For example on the OS level the /proc/sys/vm/max_map_count parameter sets the number of the maximum number of memory map areas a process may have for Linux.
But before You will mess with those settings, rethink if it is really necessary - most possibly there is another way to run the equivalent code, which makes a better use of the memory in disposal.
In this very case the 10M block consists of 1mln of calls to a procedure with different parameters provided as literals. Much better way in this case would be to load all the parameter values to a table (by sqlldr to persistent table or by simple inserts in one session to a global temporary table with rows preserved on commits) and then call a procedure by much, much smaller script on values from a cursor or get rid of PL/SQL block, turn procedure to function and call it in simple SELECT.