alter system set [parameter name]='[value1]','[value2],'[value3]';In the past this was not related to the local_listener parameter - it was one value parameter and to provide several host:port combinations one had to create multi value alias definition in tnsnames.ora.
Some time ago (few days may be) I realized that now the local_listener also allows for multiple values - in fact since 11.2.0.1.